Viagra, Cialis, Levitra Comparison

Before Viagra was developed in 1998, millions of men in America suffered from erectile dysfunction. There was no cure that really worked, and men simply had to endure their problems. When Viagra was introduced, and people discovered that it was effective and successful, they embraced it almost without question. In fact, it was accepted so fast it was soon taken for granted.

Because of the success of Viagra, several drug companies tried to follow its lead and get a share of the market https://arbuthnotdrug.com. Barely 5 years after Viagra changed the lives of millions of men, a few competitors have risen to the challenge, and men now had 3 pills to choose from – Viagra, Levitra and Cialis. These pills may sound like completely different drugs, but they are actually very similar in many ways. Even their chemical names sound similar – sildenafil, vardenafil and tadalafil.

But however you call them, they are still all competing for the $1.7 billion market formerly dominated by Viagra, and the competition is getting fiercer than ever.

These three companies have used various advertising gimmicks to promote their products, and have endorsements from celebrities such as Senator Bob Dole, coach Mike Ditka and baseball player Raphael Palmeiro. Potential customers, though, should not rely on these advertisements. They should understand the characteristics of these medications that differentiate them from one another and study literature on Viagra vs cialis, Viagra vs levitra, etc,

How do the medications work?

Viagra, Levitra and Cialis have one main thing in common – they all target phosphodiesterase-5 or PDE-5, an enzyme that’s responsible for sexual dysfunction. In order to understand how the drugs work, you must first understand how erections are formed.

Erections can only be attained when a man’s arteries, veins, and nerves are healthy and in good shape. He also has to have sufficient testosterone levels and an open state of mind. Besides these requirements, the arousal impulses must also be transmitted between nerves, and the smooth muscle cells in the arteries must be relaxed for the blood to flow more freely into the penis. These can all be done by nitric oxide (NO).

Nitric oxide triggers the production of cyclic guanosine monophosphate (cGMP) in the arteries. This is the chemical responsible for an improved blood flow to the penis. However, PDE-5 is also produced by the penis tissues, and this enzyme breaks down cGMP.

Ordinarily, the penis can produce enough cGMP for a firm erection, and also enough PDE-5 to bring down the erection upon ejaculation. But with penile dysfunction, there is no balance between the productions of these chemicals. What the medications do is recreate this balance by preventing the production of PDE-5, thus increasing the amount of cGMP. Usually, this solution is enough for men to develop erections when aroused sexually.

What are the success rates?

In laboratory tests, vardenafil (Levitra) and tadalafil (Cialis) have a slight edge over sildenafil (Viagra) when it comes to reducing PDE-5. This means that the newer medications have a higher potency than sildenafil, and that smaller doses of the newer drugs can produce similar results as higher doses of the older drug. Because they are stronger, the new drugs are marketed in lower doses as well. Vardenafil is available in 2.5-, 5-, 10-, and 20-mg pills; Tadalafil is available in 5-, 10-, and 20-mg pills; and sildenafil is available in 25, 50, and 100 mg. The higher the dose, the stronger the effect, but it also increases the risks of side effects. All three medications have more success with mild penile dysfunction compared to more serious cases.

Doctors have had much more clinical experience with sildenafil than its newer rivals. Still, all three drugs appear to achieve similar results. In broad terms, about 70% of men benefit. The response is best in men with no identifiable organic cause of erectile dysfunction (about 90%), but it’s less favorable in diabetics (about 50%), and it’s hard to predict in men who have been treated for prostate cancer.

Because sildenafil was first to be developed, doctors have more experience with this medication, but all three have been found to produce similar effects in men. Roughly 70% of men have achieved success with the use of these medications. Healthy men have had higher success rates (90%), but those who have diabetes only have about 50% chance of success. The success rate for men with prostate cancer is still difficult to determine.

What are the side effects?

If you have no health issues, all three medications are very safe. Some men experience side effects, which are usually just headaches and facial flushing. Others may also experience nasal congestion, indigestion, and back pain. A much less common side effect is visual disturbance. All side effects are usually mild and do not last long. Long-lasting side effects, such as prolonged painful erections or priapism, are extremely rare.

These drugs work on the arteries so men with heart conditions must take extra care in using them. Nitric oxide is produced in the arteries, and phosphodiesterase enzymes are required to control the production of nitric oxide. When the medications reduce phosphodiesterase, nitric oxide is increased, and the arteries are widened. The three medications all target PDE-5 which is mostly found in the penis. However there are also other arteries that have PDE-5, and the drugs have an effect on these, as well as on other related enzymes in other parts of the body. This may lead to widening of arteries in other parts of the body, and may cause low blood pressure.

There is another kind of medication that acts on nitric oxide, and these are called nitrates. They are used to enlarge the coronary arteries that are partially blocked in angina patients. However, nitrates and anti-impotence medications both work on nitric oxide, and must not be taken together. Therefore men who are using nitrates are prohibited from using sildenafil, vardenafil, or tadalafil. Among the prohibited medications are all kinds of nitroglycerin (which includes under-the-tongue tablets or sprays, also pastes and patches), long-acting nitrates such as isosorbide dinitrate (Isordil, Sorbitrate, etc.) and isosorbide mononitrate (Imdur, ISMO, etc.) as well as amyl nitrate (poppers for sexual stimulation).

The three medications for erectile dysfunction will not have harmful side effects on men with stable heart conditions, if they do not take nitrates. The drugs are also safe for men with mild congestive heart failure, stable angina, well-regulated hypertension, and those who have previously experienced heart attacks or strokes. However, if the heart attack or stroke is recent, they should not take the erectile dysfunction drugs until they have completely recovered. This also applies to men with active angina, unstable blood pressure, or other severe health problems.